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1.
Arch Sex Behav ; 2024 Apr 03.
Article in English | MEDLINE | ID: mdl-38570424

ABSTRACT

Sexual norms define perceptions of who is acceptable to partner with, how many partners are appropriate, and what sexual behaviors are acceptable to engage in. This shapes, in part, who has access to sexual pleasure and who is minoritized based on their sexuality. Though well theorized and researched for "in-person" sexuality, much less is known about sexual norms in other contexts/modalities, such as porn use and sexual fantasy, or how norms connect across these contexts. In the present study, we investigated sexual norms in porn, fantasy, and in-person sexuality, and similarities or differences between these. In an online study, gender/sex and sexually diverse participants (N = 706) manipulated digital circles representing porn use, sexual fantasy, and in-person sexuality. They used circle overlap to represent branchedness (i.e., distinction) and coincidence (i.e., similarity) in norm content, and circle size to indicate perceived norm strength. We found evidence that norm content was perceived to be more branched (i.e., distinct) than coincident (similar) and that norm strength for each context was high. This provides evidence that when people engage in each of these sexual contexts, they tend to do so through distinct normative lenses, rather than a singular lens that represents a universal set of norms applying across all sexual situations. This has implications for how we understand the associations between porn use, fantasy, and in-person sexuality, and highlights the importance of attending to sexuality in context.

2.
Am Psychol ; 2024 Mar 21.
Article in English | MEDLINE | ID: mdl-38512163

ABSTRACT

How gender identity is assessed directly shapes how students are supported in elementary schools in the United States. Despite the existence of gender diversity, calls for more inclusive science, and recommendations from national research associations and societies to incorporate and emphasize the voices of individuals with diverse gender identities, most studies exploring gender disparities in education have relied heavily on the assumption of a gender binary. As a result, the omission of diverse gender identities from educational research in the elementary years is troubling. To address this area of need, the current article summarizes the opportunities for and constraints surrounding inclusive evaluation of gender identity in the elementary school years. We begin with a brief review of common methods used to assess gender identities for children in elementary school, including the strengths and limitations of each. We next contextualize these measures by outlining the current state-level barriers to including diverse gender identities in assessments of gender. In highlighting the best available practices and the structural systems of oppression realized through state-level policies that perpetuate an inability to represent student voices across the gender spectrum, we conclude with a call to action to inspire the evolution of best practices in the service of all students. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

3.
Niger J Clin Pract ; 27(2): 174-179, 2024 Feb 01.
Article in English | MEDLINE | ID: mdl-38409144

ABSTRACT

BACKGROUND: This study aimed to compare the effect of different obturation techniques with root canal sealers on the residual filling material after retreatment using SEM. MATERIAL AND METHOD: Sixty (60) single rooted mandibular premolars were selected and instrumented with rotary files using the Mtwo system up to file size 30/.05 taper. The samples were randomly divided to two groups based on the type of sealer and three sub-groups (n=10) based on the obturating technique used. The root fillings were removed using the PTUR system files and the specimens were longitudinally sectioned while digital images were obtained from the root canals with SEM. The time required to reach working lenght were recorded. RESULTS: There was no difference in terms of the smear score when comparing both sealer and obturation technique groups in the apical third. Smear scores were significantly affected by the type of sealer and obturation technique in the medium and coronal thirds of root canals (p<0.05). Higher smear scores were obtained with GFB than AH Plus (p<0.05). The time required to reach working length with GFB was longer than AH Plus (p<0.05). CONCLUSION: Residual filling material was observed in all samples, regardless of the root canal sealer or the obturation technique used. There was a significantly lower smear scores in the AH Plus groups as compared to the GFB.


Subject(s)
Root Canal Filling Materials , Humans , Dental Pulp Cavity , Root Canal Obturation/methods , Root Canal Preparation/methods , Retreatment , Gutta-Percha , Epoxy Resins
4.
Clin Exp Rheumatol ; 2024 Feb 06.
Article in English | MEDLINE | ID: mdl-38372717

ABSTRACT

OBJECTIVES: We aimed to study whether myocardial changes are already detectable by cardiac magnetic resonance (CMR) imaging at the time of rheumatoid arthritis (RA) diagnosis. METHODS: This single-centre prospective study included 39 treatment-naive patients with early rheumatoid arthritis (ERA, symptom duration <1 year) without any history of heart disease, and 38 age- and sex-matched healthy volunteers. The disease severity was assessed with clinical evaluation (Disease Activity Score-28 for Rheumatoid Arthritis with CRP (DAS28-CRP) score) and serological testing (rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA)). The ERA patients were classified into group A (DAS28-CRP score ≥3.2, positive RF and ACPA; n=17) and group B (not fulfilling the group A criteria). The ERA patients and healthy controls underwent 1.5T CMR. RESULTS: Group A patients had significantly higher myocardial global T1 relaxation times than the healthy controls, 987 [965, 1003] ms vs. 979 [960, 991] ms (median [IQR]; p=0.041). A significant difference in T1 was found in the basal, mid inferior and mid anterolateral segments. In a multivariate analysis, prolonged global T1 relaxation time was independently associated with female sex (95% CI [5.62, 51.31] ms, p=0.016), and group A status (95% CI [4.65, 39.01] ms p=0.014). CONCLUSIONS: At the time of diagnosis, ERA patients with a higher disease activity (DAS28-CRP score ≥3.2) and both positive RF and ACPA showed prolonged T1 relaxation times in basal myocardial segments. These segments could be most susceptible to the development of myocardial fibrosis, and a segmental reporting style could be useful when estimating the first signs of myocardial fibrosis.

5.
Plast Reconstr Surg Glob Open ; 11(12): e5483, 2023 Dec.
Article in English | MEDLINE | ID: mdl-38098949

ABSTRACT

Background: The obesity pandemic in Saudi Arabia has led to a high demand for bariatric surgery (BS). Post-BS patients experience rapid and massive weight loss, with most patients experiencing redundant skin, leading to a desire for body contouring surgery (BCS). Methods: A cross-sectional study was conducted from September 2022 to May 2023 among patients who underwent BS in Saudi Arabia, using an online self-administered questionnaire. The questionnaire comprised sociodemographic data, weight, and BS-related questions, and the post-BS appearance questionnaire assessed the desire for BCS, excess skin satisfaction, and overall appearance. Results: A total of 410 of the patients electively enrolled. The mean perceived satisfaction of post-BS patients with the body's excess skin was rated as 4.28 ±â€…1.69 out of 7 points. The overall desire for BCS among the post-BS population was equal to a collective mean desire of 2.10 ±â€…0.92 out of 4 points. The desired body sites for BCS were focused on the abdomen/waist, followed by the lower back, then upper arms, buttocks, and thighs. Only 25.1% of the patients fulfilled their desires and recently underwent BCS. Conclusions: The study highlights the importance of incorporating plastic and reconstructive surgery as an integral part of the multidisciplinary approach to morbidly obese patients after BS and the need for national guidelines on the referral pathway for post-BS BCS.

6.
Allergy Asthma Clin Immunol ; 19(1): 14, 2023 Feb 24.
Article in English | MEDLINE | ID: mdl-36829257

ABSTRACT

BACKGROUND: There is a paucity of studies reporting the presence of systemic symptoms and micronutrient deficiency in patients with chronic urticaria, and these data are lacking in a Canadian population. OBJECTIVE: To report the prevalence of gastrointestinal symptoms and vitamin B12 (cobalamin) deficiency in a Canadian patient population diagnosed with chronic urticaria. METHODS: A retrospective chart review of 100 adult patients with chronic urticaria was conducted. Demographic characteristics, medications, presence of gastrointestinal symptoms, and laboratory findings were abstracted from electronic medical records. RESULTS: Seventy percent of patients with chronic urticaria reported experiencing gastrointestinal symptoms. The most common symptom identified was gastroesophageal reflux (42%). Vitamin B12 (cobalamin) deficiency, defined as serum vitamin B12 level ≤ 250 pmol/L, was identified in 31.7% of the patients. Among those patients with urticaria and vitamin B12, 68% reported gastrointestinal symptoms. CONCLUSIONS: This is the first study to provide data on the high prevalence of gastrointestinal symptoms and vitamin B12 (cobalamin) deficiency in a Canadian population diagnosed with chronic urticaria. Early recognition and management of systemic symptoms and micronutrient deficiency may lead to a more comprehensive approach to management of these patients. Trial registration Not applicable.

7.
Plast Reconstr Surg Glob Open ; 10(12): e4696, 2022 Dec.
Article in English | MEDLINE | ID: mdl-36583167

ABSTRACT

Velopharyngeal insufficiency (VPI) is a condition characterized by failure of the posterior part of the soft palate to reach the pharyngeal wall and separate the nasopharynx from the oropharynx during speech and swallowing. VPI may persist following cleft palate repair. This study aimed to determine the outcomes of the superiorly based pharyngeal flap to treat VPI post cleft palate repair. Methods: A retrospective cohort study included patients with VPI post cleft palate repair who underwent secondary speech surgery. The criteria were based on clinical symptoms, physical examination, nasometry, and videofluoroscopy/nasoendoscopy findings. Data were analyzed by using SPSS program, version 22.0. A P value less than 0.05 was considered significant. Results: Thirty-five patients were identified. VPI was reduced to 14.3% postoperatively. Before the surgery 25.7% of the patients had severe hypernasality, 68.6% had moderate hypernasality, and 5.7% had mild hypernasality. After the surgery, only 8.6% of the patients still had severe hypernasality, 22.9% had moderate hypernasality, 57.1% had mild hypernasality, and hypernasality became absent in 11.4%. Articulation disorders were present in 91.4% of patients before surgery, and decreased to 71.4% postoperatively. Speech intelligibility improved postoperatively in comparison with preoperative findings. Conclusion: The present study concluded that the superiorly based pharyngeal flap was successful in treating VPI that persisted post cleft palate repair.

8.
Arch Sex Behav ; 51(8): 3847-3870, 2022 11.
Article in English | MEDLINE | ID: mdl-36112330

ABSTRACT

Low sexual desire in women is usually studied as a problem, one that is located within women. However, other possibilities exist, including known gender inequities related to heteronormative gender roles. In this study, we provide the first test of the theory that heteronormativity is related to low sexual desire in women partnered with men, focusing specifically on inequities in the division of household labor. In two studies with women who were partnered with men and had children (Study 1, N = 677; Study 2, N = 396), performing a large proportion of household labor was associated with significantly lower sexual desire for a partner. Together, the results suggest that this association was mediated by both perceiving the partner as a dependent and perceiving the division of labor as unfair. These results support the heteronormativity theory of low sexual desire in women partnered with men, and show that gender inequities are important, though understudied, contributors to low desire in women partnered with men.


Subject(s)
Libido , Sexual Behavior , Male , Child , Female , Humans , Gender Identity , Family Characteristics , Sexual Partners
9.
Int J Transgend Health ; 23(3): 274-294, 2022.
Article in English | MEDLINE | ID: mdl-35799953

ABSTRACT

Background: Gender euphoria is an important experience and concept for many, especially transgender and/or nonbinary individuals, but has not received much attention from psychological and clinical research. In contrast to gender dysphoria, which originates in psychiatry, the term "gender euphoria" has been mobilized by some LGBTQ people to describe the powerfully positive emotions that can come from one's gender/sex. As such, researchers and clinicians may benefit from conceptual clarity as to what gender euphoria is and what kinds of experiences might result in gender euphoria. Aim: We aimed to better understand how trans community members and others conceptualize the term "gender euphoria," including its relationship to gender dysphoria, as well as the contexts and behaviors that elicit gender euphoria. Method: We administered an online qualitative survey to participants (N = 47) of diverse sexualities and gender/sexes (including transgender, cisgender, and/or nonbinary participants) who had heard of or used the term "gender euphoria." Participants answered open-ended questions about where they had heard the term being used, how they would define gender euphoria and gender dysphoria, the relation between these terms, and their gender euphoric experiences. Results: Analyses resulted in five themes: (1) gender euphoria describes a joyful feeling of rightness in one's gender/sex, (2) gender euphoric experiences can be external, internal, and/or social, (3) "gender euphoria" originated in and circulates in online and in-person gender/sex minority communities, (4) dysphoria describes a negative feeling of conflict between gender/sexed aspects of one's self, and (5) the relationship between euphoria and dysphoria is complex. Discussion: These results can inform qualitative and quantitative research, gender affirmative clinical practice, political fights for transgender rights, and understandings of gendered experiences for people of all identities.

10.
Arch Sex Behav ; 51(2): 1201-1219, 2022 02.
Article in English | MEDLINE | ID: mdl-35112269

ABSTRACT

Sexual orientation describes sexual interests, approaches, arousals, and attractions. People experience these interests and attractions in a number of contexts, including in-person sexuality, fantasy, and porn use, among others. The extent to which sexual orientation is divergent (branched) and/or overlapping (coincident) across these, however, is unclear. In the present study, a gender/sex and sexually diverse sample (N = 30; 15 gender/sex/ual minorities and 15 majorities) manipulated digital circles representing porn use, in-person sexuality, and fantasy on a tablet during in-person interviews. Participants used circle overlap to represent the degree of shared sexual interests across contexts and circle size to indicate the strength and/or number of sexual interests within contexts. Across multiple dimensions of sexual orientation (gender/sex, partner number, and action/behavior), we found evidence that sexual interests were both branched and coincident. These findings contribute to new understandings about the multifaceted nature of sexual orientations across contexts and provide a novel way to measure, conceptualize, and understand sexual orientation in context.


Subject(s)
Fantasy , Sexual and Gender Minorities , Female , Gender Identity , Humans , Male , Sexual Behavior , Sexuality
11.
J Dairy Sci ; 105(4): 3032-3048, 2022 Apr.
Article in English | MEDLINE | ID: mdl-35123782

ABSTRACT

The objective of this study was to determine the effects of milk fat depression induced by supplementing conjugated linoleic acid (CLA; trans-10,cis-12 and cis-9,trans-11 CLA) or feeding a higher starch and oil-containing diet (HSO) on metabolic changes in dairy cows after calving. The main hypothesis was that the 2 strategies to decrease milk fat yield could have different effects on performance, energy balance (EB), and inflammatory status in early lactation. Thirty-three Nordic Red dairy cows were used in a randomized block design from 1 to 112 d of lactation and fed one of the following treatments: control (CON), CLA-supplemented diet, or HSO diet. Dry matter intake and milk yield were measured daily whereas milk composition was measured weekly throughout the experiment. Nutrient digestibility, EB, and plasma hormones and metabolites were measured at 3, 7, 11, and 15 wk of lactation in respiration chambers. The HSO diet led to lower intakes of dry matter, neutral detergent fiber, and gross energy compared with CON and CLA diets. The CLA diet and especially the HSO diet resulted in lower energy-corrected milk yield during the first 7 wk of lactation than those fed CON. The EB was numerically higher for HSO and CLA diets compared with CON at wk 3 and 7. Plasma glucose concentration was higher by the CLA diet at wk 3 and by the HSO diet from wk 3 to 15 compared with CON. Plasma nonesterified fatty acids were higher at wk 3 in the CON group (indicating more lipid mobilization) but decreased thereafter to similar levels with the other groups. The HSO-fed cows had higher plasma ceruloplasmin, paraoxonase, and total bilirubin concentrations in the entire experiment and showed the highest levels of reactive oxygen metabolites. These results suggest an increased inflammatory and oxidative stress state in the HSO cows and probably different regulation of the innate immune system. This study provides evidence that milk fat depression induced by feeding HSO (as well as CLA) decreased milk fat secretion and improved EB compared with CON in early lactation. The increase in plasma glucose and paraoxonase levels with the HSO diet may imply a better ability of the liver to cope with the metabolic demand after parturition. However, the negative effect of HSO on feed intake, and the indication of increased inflammatory and oxidative stress warrant further studies before the HSO feeding strategy could be supported as an alternative to improve EB in early lactation.


Subject(s)
Cattle Diseases , Linoleic Acids, Conjugated , Animals , Cattle , Cattle Diseases/metabolism , Diet/veterinary , Dietary Supplements , Energy Metabolism , Fatty Acids/metabolism , Female , Inflammation/metabolism , Inflammation/veterinary , Lactation/physiology , Linoleic Acids, Conjugated/pharmacology , Milk/metabolism , Oxidative Stress , Rumen/metabolism
12.
J Interpers Violence ; 37(23-24): NP22199-NP22225, 2022 12.
Article in English | MEDLINE | ID: mdl-35170332

ABSTRACT

Psychological sexual coercion is known to negatively impact those who experience it, yet sexual encounters where orgasm is present are often presumed to be positive and absent of coercion. In the present study, we conducted an online survey with women (n = 179) and men (n = 251) to test associations between sexually coercive experiences that include orgasm and negative psychological, sexual, and relationship outcomes. To do so, we focused on three experiences: having an orgasm during coerced sex (CS), having a coerced orgasm during desired sex (CO), and having a coerced orgasm during coerced sex (COS). Using structural equation modeling, we found that ever having any of these coercion-plus-orgasm experiences with a current partner predicted significantly higher avoidance motivations (i.e., engaging in sex to avoid conflict with one's partner), which in turn predicted significantly worse psychological distress, sexual satisfaction, relationship satisfaction, and sexual functioning (but not dyadic sexual desire). We also found that CS, CO, and COS predicted negative outcomes to a similar degree. However, testing gender/sex as a moderator clarified that CS predicted significantly lower sexual satisfaction, sexual functioning, and sexual desire for women but not men. Furthermore, CO predicted faking orgasms in women, but COS predicted faking orgasms in men. Together, results demonstrate that experiencing psychological sexual coercion and/or orgasm coercion is significantly associated with negative outcomes even if the coerced person's orgasm occurs.


Subject(s)
Coercion , Orgasm , Female , Humans , Sexual Behavior/psychology , Personal Satisfaction , Surveys and Questionnaires , Sexual Partners/psychology
13.
Arch Sex Behav ; 51(1): 633-651, 2022 01.
Article in English | MEDLINE | ID: mdl-35059945

ABSTRACT

Trying to ensure that a partner orgasms during sex is generally seen as positive, but research has yet to assess how this might involve pressuring partners to orgasm in coercive ways. In the present study, we tested whether pressuring a partner to orgasm is a coercive behavior by assessing how this behavior overlaps with sexual coercion (i.e., pressuring someone into having sex). Participants of diverse gender/sex and sexual identities (N = 912, M age = 31.31 years, SD = 9.41) completed an online survey that asked them whether they had ever felt pressured by a partner to orgasm, to describe what partners have said or done to pressure them, and to answer a series of questions about the most recent incident in which this occurred. Mixed quantitative and qualitative results showed that orgasm pressure tactics were analogous to sexual coercion tactics and that being pressured to orgasm was associated with experiencing sexual coercion, faking orgasms, and negative psychological and relationship outcomes. Together, findings challenge the assumption that trying to ensure a partner's orgasm occurrence is necessarily positive and demonstrate that orgasm coercion exists.


Subject(s)
Coercion , Orgasm , Adult , Gender Identity , Humans , Sexual Behavior/psychology , Sexual Partners/psychology , Surveys and Questionnaires
14.
Arch Sex Behav ; 51(1): 653-671, 2022 01.
Article in English | MEDLINE | ID: mdl-35022909

ABSTRACT

Orgasm coercion involves pressuring a partner to orgasm by implying that not orgasming will have negative consequences. In the present study, we used mixed methods to explore (1) how various individual and contextual factors-i.e., frequency of orgasm coercion, orgasm frequency, gender/sex, sexual identity, the orgasm coercion tactics used, and perceptions of the perpetrator's intention-affect relationship and psychological outcomes associated with orgasm coercion, and (2) how different individuals characterize these outcomes. Cisgender women, cisgender men, and gender/sex minority participants (N = 308, M age = 30.44 years, SD = 8.16) described the most recent encounter in which they experienced orgasm coercion and then rated and described the positive and negative relationship and psychological outcomes associated with the incident. Quantitative results showed that the following predicted significantly higher negative relationship and psychological outcomes: a higher frequency of experiencing orgasm coercion, lower frequency of orgasming with partners in general, and experiencing orgasm coercion via physical or emotional threats. Believing that the perpetrator was motivated by altruism or social pressures mitigated these effects. And, experiencing orgasm coercion via implied fault predicted significantly higher negative relationship outcomes only for cisgender women. Additionally, being a sexual minority predicted higher negative relationship (but not psychological) outcomes, whereas being a gender/sex minority predicted higher negative psychological (but not relationship) outcomes. Qualitative results showed that relationship and psychological outcomes varied; for example, participants discussed making a partner happy, disappointment with their partner's behaviors, ending the relationship, and lasting feelings of anxiety, guilt, and abuse. Together, findings offer new insights into how orgasm coercion affects those who experience it.


Subject(s)
Orgasm , Sexual and Gender Minorities , Adult , Coercion , Female , Gender Identity , Humans , Intention , Male , Sexual Behavior/psychology , Sexual Partners/psychology
15.
Arch Sex Behav ; 51(1): 391-415, 2022 01.
Article in English | MEDLINE | ID: mdl-34426898

ABSTRACT

Low sexual desire in women partnered with men is typically presumed to be a problem-one that exists in women and encourages a research agenda on causation and treatment targeting women. In this paper, we present a distinct way forward for research on low sexual desire in women partnered with men that attends to a more structural explanation: heteronormativity. A heteronormative worldview assumes that relationships and structures are heterosexual, gender (usually conflated with sex) is binary and complementary, and gender roles fit within narrow bounds including nurturant labor for women. We propose the heteronormativity theory of low sexual desire in women partnered with men, arguing that heteronormative gender inequities are contributing factors. We outline four hypotheses and their predictions related to: inequitable divisions of household labor, blurring of partner and mother roles, objectification of women, and gender norms surrounding sexual initiation. We discuss some mechanisms-social, physiological, and otherwise-for the heteronormativity theory, especially related to stress, objectification, and nurturance. We close by noting some limitations of our paper and the ways that the heteronormativity theory of low sexual desire in women partnered with men provides a rigorous, generative, and empirical way forward.


Subject(s)
Libido , Psychological Theory , Sexual Partners , Female , Gender Role , Heterosexuality , Humans , Male , Sexual Behavior
16.
Inflamm Bowel Dis ; 28(3): 486-491, 2022 03 02.
Article in English | MEDLINE | ID: mdl-34473278

ABSTRACT

Inflammatory bowel diseases (IBD) including Crohn's disease and ulcerative colitis are conditions characterized by immune dysregulation to a trigger in those with a genetic predisposition. Environmental factors are thought to contribute to IBD, but no definite trigger has been identified. Aeroallergens have not been thoroughly investigated in their potential contribution to the pathogenesis to IBD. The geographic distribution of aeroallergens and IBD, the association of atopic disease with IBD, seasonality and IBD, and cross-reactive food allergens require further study with implications for targeted dietary and immunomodulatory therapies.


Subject(s)
Colitis, Ulcerative , Crohn Disease , Inflammatory Bowel Diseases , Colitis, Ulcerative/therapy , Crohn Disease/therapy , Genetic Predisposition to Disease , Humans , Inflammatory Bowel Diseases/complications
17.
ACS Nano ; 15(10): 15992-16010, 2021 10 26.
Article in English | MEDLINE | ID: mdl-34605646

ABSTRACT

Identification of HLA class I ligands from the tumor surface (ligandome or immunopeptidome) is essential for designing T-cell mediated cancer therapeutic approaches. However, the sensitivity of the process for isolating MHC-I restricted tumor-specific peptides has been the major limiting factor for reliable tumor antigen characterization, making clear the need for technical improvement. Here, we describe our work from the fabrication and development of a microfluidic-based chip (PeptiCHIP) and its use to identify and characterize tumor-specific ligands on clinically relevant human samples. Specifically, we assessed the potential of immobilizing a pan-HLA antibody on solid surfaces via well-characterized streptavidin-biotin chemistry, overcoming the limitations of the cross-linking chemistry used to prepare the affinity matrix with the desired antibodies in the immunopeptidomics workflow. Furthermore, to address the restrictions related to the handling and the limited availability of tumor samples, we further developed the concept toward the implementation of a microfluidic through-flow system. Thus, the biotinylated pan-HLA antibody was immobilized on streptavidin-functionalized surfaces, and immune-affinity purification (IP) was carried out on customized microfluidic pillar arrays made of thiol-ene polymer. Compared to the standard methods reported in the field, our methodology reduces the amount of antibody and the time required for peptide isolation. In this work, we carefully examined the specificity and robustness of our customized technology for immunopeptidomics workflows. We tested this platform by immunopurifying HLA-I complexes from 1 × 106 cells both in a widely studied B-cell line and in patients-derived ex vivo cell cultures, instead of 5 × 108 cells as required in the current technology. After the final elution in mild acid, HLA-I-presented peptides were identified by tandem mass spectrometry and further investigated by in vitro methods. These results highlight the potential to exploit microfluidics-based strategies in immunopeptidomics platforms and in personalized immunopeptidome analysis from cells isolated from individual tumor biopsies to design tailored cancer therapeutic vaccines. Moreover, the possibility to integrate multiple identical units on a single chip further improves the throughput and multiplexing of these assays with a view to clinical needs.


Subject(s)
Histocompatibility Antigens Class I , Microfluidics , Antigens, Neoplasm , Humans , Ligands , Peptides
19.
Arch Sex Behav ; 50(1): 23-43, 2021 01.
Article in English | MEDLINE | ID: mdl-33175270

ABSTRACT

Gender/sex and sexual diversity are increasingly understood by the public as complex. But, scientific frameworks that address the complexity of gender/sex and sexual diversity are few and not well situated for the public. Sexual configurations theory (SCT; van Anders, 2015) is one approach that provides a visual framework for understanding and measuring gender/sex and sexual diversity. But how might knowledge users and creators actually use it? To make SCT more accessible to researchers, educators, clinicians, and the general public, we created three instructional videos (individual gender/sex, gender/sex sexuality, and partner number sexuality) that explained SCT and demonstrated how to use its diagrams. Participants (N = 242) of diverse gender/sex and sexual identities, including professionals who work in gender/sex- and sexuality-related fields, watched one of the three videos, filled out the diagrams, and evaluated the video and diagrams via scaled and open-ended questions. Results demonstrated that the SCT videos were sufficient for most participants to fill out the diagrams. Participants evaluated the video generally positively, with some variation by condition, identity group, and professional status. These results indicate that instructional videos are able to translate SCT, potentially facilitating uptake of SCT by clinicians, researchers, and educators as well as increasing awareness of gender/sex and sexual diversity more broadly within the public.


Subject(s)
Knowledge , Sexual Behavior/psychology , Sexual Partners/psychology , Videotape Recording/methods , Female , Humans , Male
20.
Article in English | LILACS-Express | LILACS | ID: biblio-1387039

ABSTRACT

Abstract In an anonymous online study of 242 Jewish-identified participants (71 men, 163 women, 8 other; mean age = 37.8 years) living in ethnically diverse communities we found levels of antisemitism significantly associated with depression, survivor guilt proneness, and self-hate. Involvement in the Jewish community was significantly associated with life satisfaction even when adjusting for the effects of discrimination. A subsample of 124 responded to open ended questions with narratives. Thirty percent indicated feeling unsafe when identifying as Jewish.


Resumen En un estudio online y anónimo de 242 participantes identificados como judíos (71 hombres, 163 mujeres, 8 otros; media de edad = 37,8 años) que viven en comunidades étnicamente diversas, encontramos niveles de antisemitismo significativamente asociados con la depresión, la propensión a la culpa del sobreviviente y el odio a sí mismo. La participación en la comunidad judía se asoció significativamente con la satisfacción con la vida, incluso cuando se ajusta a los efectos de la discriminación. Una sub muestra de 124 personas respondió a preguntas abiertas con narrativas. El treinta por ciento indicó sentirse inseguro al identificarse como judío.

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